Once Upon a Time in the West is a soundtrack composed by Ennio Morricone, from the 1968 western film of the same name directed by Sergio Leone, released in 1972. The film score sold about 10 million copies worldwide.

The soundtrack features leitmotifs that relate to each of the main characters of the movie (each with their own theme music), as well as to the spirit of the American West. The theme music for the Claudia Cardinale character has wordless vocals by Italian singer Edda Dell'Orso.

It was Leone's desire to have the music available and played during filming. Leone had Morricone composed the score before shooting started and would play the music in the background for the actors on set.

"E Più Ti Penso" ("The more I think of you" in English), alternatively titled "E Più Ti Penso (from Once Upon a Time in America)" is an Italian song originally written by Ennio Morricone, Mogol, and Tony Renis for the movie Once Upon a Time in America. This is a song recorded by the Italian operatic-pop trio Il Volo in 2010 in their first CD Il Volo in 2010. Later this song was recorded by Italian singer Andrea Bocelli and American singer Ariana Grande. The song was released on 1 October 2015, and served as the lead single from Bocelli's album, Cinema (2015).