NápravnÃk became organist and assistant conductor at the Imperial theatres in 1863, second conductor in 1867, and chief conductor, succeeding Liadov, in 1869, holding the post until his death. He gave the first performances of Boris Godunov in 1874, five operas by Pyotr Ilyich Tchaikovsky, including The Maid of Orleans, Mazepa, and The Queen of Spades, and five by Nikolai Rimsky-Korsakov, including May Night, The Snow Maiden, and Christmas Eve. He also conducted concerts of the Russian Musical Society. In 1914, after a productive career in the service of Russian opera, he was forced to discontinue further work due to ill health.
Of NápravnÃk's own four operas the most successful was Dubrovsky (1894, staged 1895) written to a Russian libretto by Modest Ilyich Tchaikovsky after the story by Alexander Pushkin.
He died in Petrograd in 1916. In May 1917, his family went abroad and eventually settled in Belgium.